This is similar to my current setup. I’m using the 44 through one of my Carvin 2×12 combo’s speakers. The amp needs work and I run everything through a Line 6 Pod HD anyway, so I intend to get a separate cab for this rig. At the 12 o’clock position driving just one speaker (an Eminence Red Coat), the 44 is more than loud enough for live rehearsals, I’d wager that it would work just fine for a live show as well. I realize it’s not the 22, but I’ll bet the 22 through a single speaker cab will be to your liking.