Another configuration question! Is there any disadvantage to having The Silencer up front, and first to receive the guitar signal, and an entire pre-amp section of a pedalboard through its effects loop?

I have an overkill 10-11 pedal pre-amp (filter, comp, wah, pitch, octave, boost, fuzz, number of drives through a 3-way looper) for studio use. Fairly committed to the chain order and instead of testing out each and every configuration, wondering if I can set it up so and forget!