yep. you’ll need more sends, but then you can use it for paralell processing if you’d want too. Essentially you break the M13 into M13(pre) and M13(post).
The M13’s input to FXloop send is (Pre), the input comes from an fx send bus on the mixer, the fxloop send goes to its own channel.
Then the M13 return goes to an fx send bus on the mixer, and the output goes to its own channel(s) on the mixer (post).

Now as long as the (pre) mixer channel goes to whatever you want in the effects loop, and the effects loop return goes to the (post) send, it’ll behave rather identically to the typical m13 effects loop.

Also, like I said before, this opens up the possibility of paralell processing – have the guitar sound send to the (pre) and (post) channels simultaneously and both of those routed out to the amp. which is exciting. to me, anyway.

three effects sends + one master out. six effects sends if you’re sending/receiving signals in stereo.

fx send 1 – 2880 in
fx send 2 – M13 input
fx send 3 – M13 effects loop return (and probably the fx blender and everything with that between the fx send 3 output and the m13 effects loop return)

you’ll also need four input channels –

input 1 – guitar/blues driver in
input 2 – 2880 output
input 3 – M13 effects loop send
input 4 – M13 output

If you are using everything in mono, you could get by with my personal on-stage mixer of choice, the Behringer 1002B. It’s cheap, light/small, has faders for all the inputs, easy to use and doesn’t have a wallwart power supply. You’d have to use the ‘pan’ knobs and one of the outputs (either left or right) as one of the effects sends though.