Sounds like a cool idea. The only problem I can think of is the high gain/low gain switch is global. If you plug your guitar directly into it, you want it on high gain. If your effects send it a line level signal, then you want it on low gain or else you might overload it and get distortion. It’s possible you might be able to compensate by keeping the return channel drive/volume low, or by balancing levels between channels and effects without creating noise. I’m not sure. I go into one from a effects box(AdrenaLinn 3) and had to put it on low gain because the box would drive it too hard.